A total of 473 informed-consenting, non-diabetic postmenopausal women, without overt cardiovascular disease, were included in this study. Using receiver operating charecteristic curve analysis, it was found that, by lowering the value of TYG index to 4.0215, sensitivity improved to 78.3% (from 39.13%) with specificity of 70%. Ultrasound is generally the principal method for detecting liver steatosis but it's costly, operator-dependant, or not fully available. insulin resistance cut off is placed at the TyG index value of 4.49, with a sensitivity of 82.6% and specificity of 82.1% (AUC=0.889, 95% CI: 0.854-0.924) Subjects with an index of 4.49 or greater are likely to suffer from insulin resistance. J Clin Endocrinol Metab. Sixty-eight children with NAFLD were selected as study subjects, and 68 healthy children enrolled during the same period served as controls. Giuliani A, Zuccarini M, Cichelli A, Khan H, Reale M. Int J Environ Res Public Health. Cardiovasc Diabetol. �jE�Ev�m:.��c|�+s[�hopJcTnA&* �J2t������Y��D��MC�p[q�q_q/�cWYԲ�M���p��)s�S �cZ��S�T��_ !vg 2020 Aug 5;17(16):5655. doi: 10.3390/ijerph17165655. Results: The cut-off point for the TyG index was 8.8 in men and 8.7 in women; the respective values for TG/C-HDL were 3.1 in men and 2.2 in women. Abstract. 0000087168 00000 n 0000012933 00000 n Mean Platelet Volume Is Closely Associated With Serum Glucose Level but Not With Arterial Stiffness and Carotid Atherosclerosis in Patients With Type 2 Diabetes. 2020 Sep 12;19(1):137. doi: 10.1186/s12933-020-01108-2. Receiver operating characteristic curve analysis was used to find valid cut-off values of the TyG index for metabolic syndrome. Would you like email updates of new search results? The total number of eligible participants was 3,164 in the US and 4,873 in Korea. Subclinical atherosclerosis risk markers in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis. 0000007718 00000 n Background: 0000087428 00000 n Using a TyG-Index cut-off value of 8.0 in the lean subpopulation, women above the cut-off had 44.1% prevalence of subclinical atherosclerosis compared to 29.4% in women below the cut-off (p=0.043). 19 0 obj <> endobj 0000008290 00000 n IR was assessed using the TyG index with a cutoff value of > 4.68. Triglycerides/glucose index is a useful surrogate marker of insulin resistance among adolescents. }��������[_�q��s�V��Y��{����5���%�O��j�V\. 0000005792 00000 n Please enable it to take advantage of the complete set of features! The predictive value of this cut-off improved after considering the non-modifiable factors of old age and male sex. This study explored the diagnostic value of pentraxin 3 (PTX-3) and the triglyceride-glucose (TyG) index for NAFLD in children. The optimal TyG index cut-off for predicting CAD was 8.44 (sensitivity 47.9%; specificity 68.5%; area under the curve 0.600; P < 0.001). Copyright © 2017 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). The cut-off points discriminating MS were 8.8 and 8.7 for men and women respectively in the TyG index; the corresponding values for the TG/HDL-C were 3.1 and 2.2 for men and women respectively. Bethesda, MD 20894, Copyright FOIA Discriminatory accuracy and cut-off values for triglyceride/HDL-C ratio, LAP, VAI, and TyG index in identifying subjects with insulin resistance defined as the bottom quartile of M FFM values Correlations of surrogate indexes of insulin resistance with cardiometabolic risk factors and subclinical vascular damage and stiffness The optimal cut-off value of TyG was derived from the point with the maximum Youden index. 0000011117 00000 n 0000106905 00000 n 0000128241 00000 n 0000087867 00000 n Recently reported TyG index is reliable and accessible indicator of metabolic syndrome. H�\�͊�@�}���&j�O"ؚ��8� 1)��C��~��4=0��HR�_���~���1�߇k}�c8�]3���>�1����"4m=~��~�K�gyZ|x��x�w�k�Z��G:y�Gx�4�c|��oC��;��_��s����/��,�ס��t�/U���ĐO�^�M:ߎ�����? These two simulated ranges change to 8.9-9.4 and 4.8-5 for abnormally high FPG and TG values respectively. 0000006472 00000 n startxref 0000001773 00000 n Using a TyG-Index cut-off value of 8.0 in the lean subpopulation, women above the cut-off had 44.1% prevalence of subclinical atherosclerosis compared to 29.4% in women below the cut-off (p=0.043). Triglyceride glucose index for the detection of asymptomatic coronary artery stenosis in patients with type 2 diabetes. Triglyceride Glucose Index Is Associated With Arterial Stiffness and 10-Year Cardiovascular Disease Risk in a Chinese Population. eCollection 2021. The positive likelihood ratios and post-test probabilities for these parameters were 5.8 vs 3.1 and 72% vs 58% respectively. TyG index is presented in 10th percentiles by gender and ethnicity. Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai Study. To investigate the association between Triglyceride-glucose (TyG) index and the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Matsuda indices in Greek obese children and adolescents, in order to assess whether it could be used as a predictor of insulin resistance. 0000001456 00000 n The present study aims to examine the association of the metabolic syndrome (MS) as well as of the triglyceride-glucose index (TyG-Index), a novel marker of insulin resistance, with subclinical atherosclerosis in a cohort of postmenopausal women, stratified according to their body mass index. Complications like impaired glucose tolerance and diabetes mellitus due to iron overload need early identification in thalassemia. 0000134849 00000 n The area under the ROC curve (AUROC) of TyG for predicting severe COVID-19 patients was 0.664 (95% CI 0.576–0.751) (P = 0.001). 0000066934 00000 n The cut-off values of triglycerides and glucose index for metabolic syndrome in American and Korean adolescents. Patient divided into two groups according to the 8,55 level as cut-off value for TyG index. [ Links ] 5 Moon S, Park JS, Ahn Y. Kamińska MS, Cybulska AM, Panczyk M, Baranowska-Bosiacka I, Chlubek D, Grochans E, Stanisławska M, Jurczak A. Int J Environ Res Public Health. 0000011462 00000 n Respir Med. In conclusion, TyG index is effective to identify individuals at risk for metabolic syndrome. The impact of triglyceride-glucose index on incident cardiovascular events during 16 years of follow-up: Tehran Lipid and Glucose Study. 2017 Feb;123:18-27. doi: 10.1016/j.rmed.2016.12.004. Abstract Background Obesity and metabolic syndrome are growing health problems in western countries. <<40B0FE2A4EF0F040945F429772EAEEC9>]/Prev 156781>> 0000088829 00000 n 367 children (47.7% boys) with mean age of 9.9 ± 2.3 years, who were investigated for obesity, were … Clipboard, Search History, and several other advanced features are temporarily unavailable. The TyG equation is: 0000002377 00000 n 4 Kang B, Yang Y, Lee EY, Yang HK, Kim HS, Lim SY, et al. 0000007985 00000 n 2015 Sep;100(9):3502-8. doi: 10.1210/JC.2015-1540. Epub 2016 Aug 9. 0000019630 00000 n 0000135308 00000 n Epub 2017 Jul 4. Barzegar N, Tohidi M, Hasheminia M, Azizi F, Hadaegh F. Cardiovasc Diabetol. Similarly, the optimal cutoff value of TyG index for predicting insulin resistance as evidenced by Matsuda was 7.91 with sensitivity 85% and specificity 61%. 0000012372 00000 n h�b``�a``Se`c`p�� Ȁ ��@Q�5O���@$�ˤf�\��)}��"�(���f2)Ytt4��/S�E m�`I~�9L�?t6c�f����\"���`�`��ް�� K�4��� '����2�l����?��0�0&���v���y�ly:|j_���5 �p~\`����� �l>��(��������A� ��8j 2020 Sep 29;19(1):155. doi: 10.1186/s12933-020-01121-5. 0000004237 00000 n %%EOF 0000005154 00000 n In 10 studies, comprising a total of 63,500 subjects, TyG index diagnostic performance was evaluated using the HOMA-IR index as the reference test [7, 12, 14–21].The cutoff values were reported in 5 (4.55–4.78) with sensitivity and specificity values ranging from 73% to 90% and 45% to 99%, respectively (Table 3). The TyG index was found to have an incremental impact on CAD (OR, 1.473; 95% CI, 1.026-2.166; P =.036) in a multivariate regression analysis. Keywords: Lambrinoudaki I, Kazani A, Armeni E, Rizos D, Augoulea A, Kaparos G, Alexandrou A, Georgiopoulos G, Kanakakis I, Stamatelopoulos K. Gynecol Endocrinol. 0000007533 00000 n 0000134199 00000 n We studied the proportion of insulin r Hence, we recommend a newer lower cut-off value of 4.0215 for TYG index for better sensitivity and specificity in identifying insulin resistance. 0000067115 00000 n Hence, we recommend a newer lower cut-off value of 4.0215 for TYG index for better sensitivity and specificity in identifying insulin resistance. Epub 2015 Jun 29. 0000087892 00000 n Guo W, Zhu W, Wu J, Li X, Lu J, Qin P, Zhu C, Xu N, Zhang Q. COVID-19 is an emerging, rapidly evolving situation. 2019 Jul 25;18(1):95. doi: 10.1186/s12933-019-0898-x. This is a non-invasive prediction tool that reflects the liver fat content in non-alcoholic liver fat disease to help with diagnosis efforts. 0000010658 00000 n 0000107241 00000 n We found the AUC of the optimal cut-off value of 9.456 was poor, suggesting that it is difficult to predict hard endpoint events based on the TyG index alone. This brief survey explored a simple but potentially important inconsistency about TyG index value. Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact. 0000128629 00000 n 19 58 0000067046 00000 n 2020 Jul 13;17(14):5033. doi: 10.3390/ijerph17145033. Multivariate analysis showed that subclinical atherosclerosis was predicted by MS, in the overweight/obese group (OR=2.517, 95% CI: 1.078-5.878, p=0.033), and by the TyG-Index the lean group (OR=3.119, 95% CI: 1.187-8.194, p<0.001). endstream endobj 20 0 obj <>>> endobj 21 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 581.102 779.528]/Type/Page>> endobj 22 0 obj <> endobj 23 0 obj <> endobj 24 0 obj <> endobj 25 0 obj <> endobj 26 0 obj <> endobj 27 0 obj <> endobj 28 0 obj <> endobj 29 0 obj <>stream Also, ultrasound only detects steatosis if it is present in more than 20-30% of hepatocytes. The TyG-Index is associated with carotid atherosclerosis and arterial stiffness mainly in lean postmenopausal women, while the MS serves as a better predictor of subclinical atherosclerosis in overweight/obese women. Methods: Unable to load your collection due to an error, Unable to load your delegates due to an error. Laboratory results, oncological outcomes and survivals were comparised statistically between groups. Privacy, Help The diagnosis of NAFLD requires a liver biopsy, which is difficult in children. Receiver operating characteristic curve analysis was used to find valid cut-off values of the TyG index for metabolic syndrome. Wang LY, Zhu YN, Cui JJ, Yin KQ, Liu SX, Gao YH. Zhao S, Yu S, Chi C, Fan X, Tang J, Ji H, Teliewubai J, Zhang Y, Xu Y. Cardiovasc Diabetol. Published by Elsevier B.V. All rights reserved. 0000035327 00000 n 0000006725 00000 n Table 4 shows the indicators used to determine the discriminatory capacity of the cut-off points obtained for the TyG index and the TG/HDL-C ratio in the study groups. The optimal cut-off value of the metabolic syndrome was 8.81 for TyG index (sensitivity 86.7%, specificity 80.1%) and area under the ROC curve (AUC) was 0.894. TyG formula applied out off the square bracket these TyG index values approximately fall to around the half ranges: ie 4.080-4.808. 76 0 obj <>stream 0000004124 00000 n Background . The optimal cut-off point of TyG was 8.5, with a sensitivity of 87.1% and specificity of 38.2%. 2021 Mar 19;8:585776. doi: 10.3389/fcvm.2021.585776. 0000002560 00000 n 0000004348 00000 n The triglyceride and glucose index (TyG) has been proposed as a marker of insulin resistance. Then, TyG index … Markers of subclinical atherosclerosis in patients with aortic valve sclerosis: A meta-analysis of literature studies. 0000002968 00000 n Conclusions: TyG index can predict the onset of CRC. For early detection of CRC, we should encourage people with high TyG index to undergo screening for CRC. Arterial stiffness; Carotid intima-media thickness; Insulin resistance; Postmenopausal women; Subclinical atherosclerosis; Triglyceride–glucose index. Data were analyzed with sampling weights to account for multistage and stratified sampling. 0000127994 00000 n 0000011850 00000 n According to a study by Salazar et al. 0000003708 00000 n 2018 Jan;34(1):78-82. doi: 10.1080/09513590.2017.1344208. The cutoff point with a higher sensitivity value in relation to the specificity was chosen to use the TyG index for early identification of IR, so children with a TyG index higher than 7.88 should be considered as having a higher risk for IR development, when compared to those with lower TyG values, and not as already showing IR. The metabolic syndrome is associated with carotid atherosclerosis and arterial stiffness in asymptomatic, nondiabetic postmenopausal women. Because of this, there is a real interest in developing prediction tools that are both non-invasive, inexpensive and reliant on already collected data. endstream endobj 30 0 obj <> endobj 31 0 obj <>stream 0000000016 00000 n 0000106652 00000 n RESULTS: Mean ages of patients were 64.32±6.1 years and median follow-up time was 61.6±35 (range 4 … In fact, we compared area under the curve (AUC) of TyG index with that of the known risk factors of the CRC: BMI, smoking, alcohol consumption , TC, and TG . The Effect of Whole Blood Lead (Pb-B) Levels on Changes in Peripheral Blood Morphology and Selected Biochemical Parameters, and the Severity of Depression in Peri-Menopausal Women at Risk of Metabolic Syndrome or with Metabolic Syndrome. The TyG-Index correlated significantly with carotid IMT (r=0.155, p=0.012) and PWV (r=0.157, p=0.013) only in the group of lean women. The TyG index is a simple, cost-effective surrogate marker of insulin resistance among adolescents compared with … National Library of Medicine 0000058051 00000 n 0000042682 00000 n To estimate valid cut-off values, TyG index was analyzed using multivariate logistic regression analysis and the ROC curve for metabolic syndrome. 8600 Rockville Pike Di Minno MND, Di Minno A, Songia P, Ambrosino P, Gripari P, Ravani A, Pepi M, Rubba PO, Medda E, Tremoli E, Baldassarre D, Poggio P. Int J Cardiol. PMID: 29227325 Careers. The cut-off of the TyG index for diagnosis of insulin resistance was 8.18. The cut-off values for MS in the overall population were 8.8 for the TyG index (sensitivity=79%, specificity=86%), and 2.4 for the TG/HDL-C ratio (sensitivity=88%, specificity=72%). 0000006043 00000 n 9�A�~�c+���������e���a�O�� �{�z��u&����&\�cm��t�ʯW'�xl ��͞ ���[�������[4�[��u���=�\�%h@J08�ы xref Front Cardiovasc Med. 0000013406 00000 n We aimed to investigate the ability of TyG, through comparing with the predictive value of alanine aminotransferase (ALT), to identify individuals at risk for nonalcoholic fatty liver disease (NAFLD). The TyG-Index may prove a useful marker for identifying high-risk women in the normal-weight postmenopausal population. 0000004595 00000 n However, by adding the TyG index into established risk factors of MACE, we found a significant improvement in risk prediction in terms of the C-statistic value, NRI and IDI. 0000134542 00000 n 0000004908 00000 n Int J Obes. %PDF-1.4 %���� 0000012243 00000 n Using receiver operating charecteristic curve analysis, it was found that, by lowering the value of TYG index to 4.0215, sensitivity improved to 78.3% (from 39.13%) with specificity of 70%. The AUC was 0.75 (p < 0.001). 0000088393 00000 n 0000009179 00000 n Prevention and treatment information (HHS). Accessibility We aimed to compare the association between structural and functional indices of subclinical atherosclerosis (i.e. Diagnostic Accuracy of the TyG Index against HOMA-IR. This site needs JavaScript to work properly. trailer 0000010030 00000 n In this context, the predictive power of the TyG index to early identify diabetes onset was compared with FPG and triglycerides. Methods . 0000135722 00000 n 0000001890 00000 n For TyG index quartiles, hazard ratios (HRs) of quartiles 3 and 4 were 4.06 (p = 0.033) and 5.65 (p = 0.006) respectively. carotid artery intima-media thickness (IMT), flow-mediated dilation of the brachial artery, pulse wave velocity (PWV)) with the TyG-index or MS, separately for lean and overweight/obese women. Conclusions: The optimal cut-off value with the Cook et al. Epub 2016 Dec 8. 2016 Nov 15;223:364-370. doi: 10.1016/j.ijcard.2016.08.122. H�\P�j�0��+t�=,ΣGc([ 2017;41:789-92. 0000133926 00000 n 41 When analyzing the areas under the curves, the P value obtained was statistically significant, indicating that the TyG index was a better predictor than FPG (P = 0.004) and triglycerides (P = 0.034), when the glucose level was under 100 mg/dL. The total number of eligible participants was 3,164 in the US and 4,873 in Korea.
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