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CRO Jobs PubMed:Plasma and urine concentrations of diazepam and its metabolites in children, adults and in diazepam-intoxicated patients. A)    Sugar Moiety    B),    Glycoside Moiety B)    preparation of SOP Naphthalene glycoside isolated from senna leaves and pods is B)    patient compliance Clarke [6] reported the following thin-layer chromatographic system: Plates: Silica gel G, 250 μm thick, dipped in, or sprayed with 0.1 M potassium hydroxide in methanol, and dried. Isoxicam C)    Annual inventory + Annual purchase C)    Grey room    D)    White room. 59. The sample taken by the Drug Inspector from the retail premises should be divided into On the contrary, bentazepam belongs to a different drug sub‐group called tienodiazepines, which differ in their chemical structure, by the substitution of the benzene ring by a tiofene ring adhered to the diazepinic ring, maintaining the other benzene ring in the 5’ carbon extreme. Diazepam increases the activity of gamma-aminobutyric acid (GABA), a … The organism used for the production of Dextran is, 62. Reserpine is contraindicated in patients with a histoiy of Schick test is performed for testing the individual for the presence of. Excessive drowsiness and with longer-term use, drug dependence, are the most common side effects of prazepam. C) in vivo and tn vitro    D)    neither in vivo nor in vitro. Drugs Technical Advisory Board ( DTAB )-Allopathy consists of 18 members whereas DTAB -Ayurvedic, Siddha and Unani drugs consists of C)    C-Glycoside,    N-Glycoside So far, a total of at least six receptor subtypes, BzR1-BzR6, have been cloned and sequenced from mammalian brain, which derive from the combination of different subunits. The first pharmaceutical product to be produced by mammalian cell culture is For instance, Neuropathology of Drug Addictions and Substance Misuse, Challenges in Confirmation Testing for Drugs of Abuse, Accurate Results in the Clinical Laboratory, Oxazepam-d5, diazepam-d5, nordazepam-d5, lorazepam-d4, Diazepam-d5, nordiazepam- d5, oxazepam-d5, flunitrazepam-d7, clonazepam-d4, 7-aminoflunitrazepam-d7, alprazolam-d5, 7-aminoclonazepam-d4, 7-Aminoclonazepam-d4, 7-aminoflunitrazepam-d7, clonazepam-d4, 7-Aminoclonazepam-d4, 7-aminoflunitrazepam-d7, clonazepam-d4, flunitrazepam- d7, alprazolam-d5, temazepam-d5, desalkylflurazepam-d4, oxazepam-d5, nordiazepam-d5, triazolam-d4, lorazepam-d4, prazepam-d5, diazepam-d5, 7-Aminoflunitrazepam-d7, flunitrazepam-d7, oxazepam-d5, lorazepam-d4, temazepam-d5, diazepam-d5, nordiazepam-d5, 7-Aminoflunitrazepam-d7, α-hydroxytriazolam-d7, nordiazepam-d5, nitrazepam-d5, Alprazolam-d5, diazepam-d5, flunitrazepam-d7, oxazepam-d5, zopiclone-d4, Alprazolam-d5, alpha-hydroxyalprazolam-d5, diazepam-d5, nordazepam-d5, oxazepam-d5, 7-aminoflunitrazepam- d7, flunitrazepam-d7, lorazepam-d4, Liquid–liquid extraction (diethyl ether-chloroform), Actetate buffer (pH=4)+beta-glucuronidase/arylsulfatase for 2, Solid-phase extraction (Chromabond C18ec columns), Solid-phase extraction (mixed-mode isolute HCX columns), Dichloromethane/methanol/ammonium hydroxide, under ultrasonication for 1, Solid-phase extraction (BondElut Certify columns), Liquid–liquid extraction (dichloromethane/ether), Liquid–liquid extraction (methylene chloride/diethylether), Liquid–liquid extraction (saturated ammonium chloride buffer+1-chlorobutane), Liquid–liquid extraction (phosphate buffer/dichloromethane), Solid-phase extraction (mixed-mode cation exchange-hydrophobic phase extraction columns), Methanol/acetonitrile/ammonium formate, at 37°C for 18, Solid-phase extraction (Clean Screen column), Water/acetonitrile/trifluoroacetic acid, using a 5, Phosphate buffer (pH 8.4), under ultrasonication for 1, Liquid–liquid extraction (dichloromethane-diethylether), Liquid–liquid extraction (hexane:ethyl acetate) +solid-phase extraction (Strata-X cartridges), Methanol/acetonitrile/formiate buffer (pH 3), 18. 131. It is the major metabolite also of clorazepate and prazepam. Peak blood levels are achieved within an hour after oral dose. C)    1960    D)    1987. Medication errorsi include In the second, simpler scheme, synthesis begins with 7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one (5.1.1), which is alkylated by cyclopropylmethylbromide in the presence of sodium amide into prazepam (5.1.11) [11,12]. I use it at a very low dose - 2 mg - 10 mg daily on an as needed basis. A)    Scrophulariaceae  B) Umbelliferae 118. 18. C)    Fluorimetry    D)    all of these. Most procedures detect oxazepam, nordiazepam, temazepam, α-hydroxyalprazolam, and diazepam at a minimum. Wikipedia. II. A) Asthma Which of the NSAIDS would be of particular use in an arthritic patient who has difficulty in remembering to take his/her medication during the day ? b)    Prochlorperazine 2. A)    list of books    B)    list of bulk drugs B)    permeation enhancer of lipophilic drugs C)    Linum usitassimum    D)    none of these. In constitution of State Pharmacy Councils total number of Registered Pharmacists to be elected is III. In the Drugs f Price Control) Order. II. 27. Isosulfan blue: Diazepam may decrease the excretion rate of Isosulfan blue which could result in a higher serum level.  A) Salmonella typhi    B)    Vibrio cholerae Which type of glycoside is present in aloes ? The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. Ph.D Alerts Larry A. Broussard, in Accurate Results in the Clinical Laboratory, 2013. Pharmacokinetic characteristics refer to the method by which benzodiazepines reach the brain regions when they are consumed. Analgesic with N-Aryl anthranillic acid nucleus is, 121. A)    Cetirizine and Cromolyn sodium             A)  5-HT partial agonist This drug is made according to a scheme very similar to … Drug information sources include all, except. 39. The adulterant of purple Foxglove leaves is 13. A)    phenytoin    B)    lidocaine 166. D) Hyperthyroidism, 136. A single-blind, parallel group, multi-centre study was carried out in 2009 patients with an anxiety state to compare the efficacy, tolerance and withdrawal effects of prazepam and diazepam in therapeutically equivalent doses. C)    ( + ) racemic mixture of quinine p) none of these. IPR Jobs 26. D)    none of these. Which drug is used to prevent embolism in the lung and during myociardial infarction ? However, there are specific immunoassays designed specifically for flunitrazepam detection. A compartment is best defined as, 3. As per GMP, change rooms to the aseptic areas of sterile product manufacturing area should be clearly demarcated into the following rooms, except A)    Membrane filter    B)    Condenser Katharometers & Bolometers are different types of Digitalis produces bradycardia by the following mechanisms, except The ideal way to provide iron for a root culture would be to include From the given pairs of diuretics in which pair both the drugs do not require the presence of aldosterone to produce diuresis ? C)    4th    D)    5th. C)    Deoxy Sugar Moiety    D)    Both (A) and (B). A)    DPT    . 76. C)    Arterial vasodilators    — Clonidine C) Thiazole    D)    Pyridine. B)     Rhein-1 -glucose Brodie RR, Chasseaud LF & Taylor T (1981) Concentrations of N- descyclopropylmethyl-prazepam in whole-blood, plasma and milk after administration of prazepam to humans. In IR spectrum, the functional group region is, 91.A sample is withdrawn or seized from drug store by a drug inspector and sealed. Table 8.3 presents a selection of internal standards used in methods dedicated to analysis of benzodiazepines and related compounds in hair. 122. 44. A)    5-8    B)    6-8 C)    acetyl coenzyme-A    D)    glucuronic acid. Cholestyramine will probably interfere with the GI absorption of, 197. D)    improve the absorption of magnesium hydroxide. Fourier transform Raman and infrared spectra have been recorded of diazepam (7‐chloro‐1,3‐dihydro‐1‐methyl‐5‐phenyl‐2H‐1,4‐benzodiazepin‐2‐one) and four compounds with closely related structures. In the lidocaine series of local anaesthetics increasing the length of the alkylene chain up to three carbon units    the local anaesthetic potency. C)    Both (A) and (B)    D) None of these. Benzodiazepines are prescription antianxiety, anticonvulsant, sedative drugs that are Schedule IV controlled substances. The list of disease for which advertisement banned or prohibited is finalised in consultation with A potent tranquilizer which also exhibits strong hypotensive effect Is C)    provide an acid medium A)    facilitated diffusion    B)    pore transport ' 56. In inventory control the turnover rate is calculated by which of the following formulae ? Flumazenil is a benzodiazepine antagonist marketed for benzodiazepine or alcohol overdose. 84. u    B) Revalue     A)    tissue culture    B)    hairy root culture 190. 1 formulary drug 2 Rapid onset = within 15 minutes, Intermediate = 15-30 minutes, Slow = 30-60 minutes Rapid onset = within 15 minutes, Intermediate = 15-30 minutes, Slow = 30-60 minutes C)    < 500 Da,    5  - 9     Of the given pairs of antihistamines, the pair in which both are, ‘dual-acting’ antihistamines is         A)    India    B)    Arabia All of the following drugs are believed to undergo significant first-pass hepatic biotransformation, except, 6. B)    Raw material manufacturers' detail The Drugs and Cosmetics Rules were passed in the year of. 153. 95. Match them correctly : C)    settle quickly and can be easily redispersed Match List I correctly with List II and select your answer using the codes given below ; Information About GPAT and Other enterances, Pharmacy Recruitment at AIIMS | Emolument Rs.35000 pm, Opportunity for Ph.D, M.Pharm as JRF at Acharya & BM Reddy College of Pharmacy, CCRAS invites applications for Senior Research Fellow | M.Pharm, M.Sc apply, Career for M.Pharm to work in ICMR Funded project at Acharya & BM Reddy College of Pharmacy, Pfizer looking for Drug Regulatory Affairs | Ph.D, M.Pharm, M.Sc, Vacancy for M.Pharm, B.Pharm in Injectable Production at Dr. Reddy's Laboratories. All BZDs are prescription-only medicines (mainly by GPs) but their duration of prescription is limited according to their respective indication (3 months for BZD anxiolytics, 4 weeks for BZD hypnotics). Within the i provision of D & C Act it is, 96. Subscribe to Pharmatutor Job Alerts by Email. O Fab fragments of Digoxin antibody D) Sodium. 187. Which of the following is/are objective(s) of purchasing ? The mechanism of action of rifampicin involve (a) Inhibition of bacterial DNA directed RNA polymerase C)    Central Drugs Laboratory 53.Whooping cough vaccine employs killed cell of Keller-Kiliani is a colour test specific for the identification of In mass spectroscopy for chemical ionization which reactant gas is most widely C)    both (A) and (B)    D)    none of these. 79. A)    Reordering level    B)    Minimum level for injection. 175. 55.A significant number of antibodies    now in use belongs to Immunoglobulin, a)    Chlorpromaztne  1. The principles of ICH guideline for GCP have their origin in Diazepam, first marketed as Valium, is a medication of the benzodiazepine family that typically produces a calming effect. 82. Hospital pharmacy deals with B) direct stimulation of vagal centre From callus, root growth can be enhanced by 32. In 15 double-blind placebo-controlled studies with the same protocol, all the data were pooled to evaluate the … Recoveries were 87.2–87.9%. Colestipol is a/an    drug. B)  III Only Digitalis leaves should be dried below, 171. C)    blocking the conduction of impulses 99. A)    18 members    B)    20 members 119. A)    < 500 Da,    1  -  5   Benzodiazepines, among the most frequently prescribed drugs in the United States, include alprazolam (Xanax), chlordiazepoxide (Librium), clonazepam (Klonopin), diazepam (Valium), estazolam (ProSom), flunitrazepam (Rohypnol), flurazepam (Dalmane), lorazepam (Ativan), midazolam (Versed), oxazepam (Serax), prazepam (Centrax), quazepam (Doral), temazepam (Restoril), and triazolam (Halcion). D)    Hofmeister rule. Interpretation of urinary metabolite results is difficult because the metabolism of different benzodiazepines often results in common metabolites such as oxazepam, temazepam, and nordiazepam. With the exception of flunitrazepam, those listed are available for use in the United States.  A) stainless steel    B)    borosillcate glass The organism used for the production of Dextran is C)    MEDLINE    D)    Science Citation Index. Q    Calcium channel blockers    D)    Sodium channel openers. Brotizolam, clotiazepam and etizolam also belong to this group. Pharm.D Alerts C)    Fluphenazine    D)  Fluoxentine. D)    opiate withdrawal syndrome. A)    to release drug in the intestine A)    C-glycosides    B)    O-glycosldes Answer-A. 6.6, GC-MS selected ion chromatograms of a spiked serum sample after LLE and silylation for screening of 51 drugs including zolpidem are shown (taken from ref. 83. Dimethyl sulphoxide is commonly used as an excipient in transdermal patches as D)    Fungal cells. A)    Atomic Absorption Spectroscopy    B)    Flame Photometry 53.Whooping cough vaccine employs killed cell of, 54.Which one of the following is the suitable site of self-injection of interferons. A)    Annual purchase + Annual inventory This is acylated by phthalimidoacetic acid chloride. A) fibrinogen    B)    fibrin foam A)    exposure to sunlight helps conversion to active metabolite C)    glass plate 176. Transdermal drug delivery systems contain drugs meant for 180. A)    blocking the metabolism of GABA B) Carbachol Dimethyl sulphoxide is commonly used as an excipient in transdermal patches as, 4. Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990). A) 5' position    B)    31 position Cholestyramine will probably interfere with the GI absorption of 104. Some psychoactive phenothlezines listed below have the following side chains at position 10, which are given in 1 to 4. Rhein-8 diglucoside Most of these medications affected two chemical neurotransmitters, norepinephrine and serotonin. This is cumbersome and not realistic in many settings. Drugs causing allergic reactions generally act as, 128. D)    atmospheric changes. The drugs that show antagonistic effects in nature whereby the sensitivity of the tissues to one drug is altered by another drug, are, 186. How many representatives are nominated by the Central Government to Drug Consultative Committee ?  A) 10% to 18%    B)    4% to 8% C)    2 parts    D)    5 parts. Drugs having hydroxyl or carboxylic acid group can easily conjugate with, 144. 170. Side effects of prazepam are less profound than with other benzodiazepines. 48Transfer of genetic material from one bacterium to another bacterium through bacteriophage is called [359] transformed zopiclone to the known decomposition product during a SPE procedure. D)    Spiranolactone and Amiloride. A)    vesicular transport    B)    engulfment of small solutes A)    Type A    B)    Type B … For example, diazepam (Valium) is a relatively powerful hypnotic (sleep inducer), whereas the more modern benzodiazepines such as alprazolam (Xanax), lorazepam (Ativan), and clonazepam (Klonopin) are less powerful hypnotics, but are very powerful anxiolytics. A)    number of waves per unit of length C)    hypotonic solution    D)    iso-osmotic solution. C)    both (A) and (B)   89. How many representatives are nominated by the Central Government to Drug Consultative Committee ? C)    dallies    D)    online pharmacy journals. Benzodiazepines that are not metabolized to oxazepam or nordiazepam, such as flurazepam, alprazolam, lorazepam, clonazepam, and triazolam, may not be detected by immunoassays.

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