Today she has fallen 2 or 3 times in the last 8 hours). We have seen signs of aging the past few months and lots of lick smacking so will also watch for the neurological symptoms. I hope the best for you and dog, I know its a tough time. My dog has been vomiting with diarrhea plus he has bumps all over his body from one dose of simparica trio. Again our dog had a major seizure in January and we searched for a neurologist ear by. He seems dehydrated. . If undiagnosed he would have died. The vet told me to switch to Simparica trio after they stopped seeking revolution which he had been on for many years. The ONLY thing that could cause such a huge change in behavior and personality had to be giving him the Simparico Trio the previous week. He is very friendly with other people and pets and never had an issue in that regard. If she recovers, cause is the Simparica. Hi there, my dog has been taking simparica trio for two months. My lab puppies have been taking Simparica Trio for 2 months. Took to vet and she said it could be the Simparico Trio. It's 5:53pm and he's acting very lethargic. 100% effective, zero side effects. Side effects are rare and may include: Neurologic side effects have been seen after using medications in this class of drugs. Most of us dog parents use some form of heartworm prevention for our dogs. Another one of our dogs also has had several episodes of suddenly crying as if she is in great pain and also began within a week of administering the poison (please don't call this a medicine, it is a poison intended to kill fleas and other bugs and in this case it can also kill your doggie). My French bulldog 2 years olds had a second attack in 3 days. Our 6 year old, 66# Treeing Walker Coon Hound baby has been taking Simparica for about two years. How is ur puppy? Is it just me or does it seem like everyone is in this together? It's only available with a prescription from your veterinarian, so you . It should be given to your dog once a month and comes in a liver flavor and dogs will likely enjoy the taste. I have to turn him around and lead him away. The vet said the simparica didn't cause the disease but it could have been the link that pushed him into the Crisis. She had terrible watery diarrhea and is not interested in eating. Vet took blood yesterday should get results today. Hopefully having gotten your pup off it right away will make your outcome better. And he was on Comfortis before and did fine. Currently we are monitoring him closely-hes never been sick. I just gave him heartgard and nexgard about 2 weeks with no issues. Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. Her heartbeat was more of a vibration than a beat and the vet wanted her to see a cardiologist. What is a good replacement? . I hate that I did this to her and I hate that the Vet does not seem to care. The following day she got diarrhea and was extreemly quiet. Today he wont eat, is sleeping all day, and when he is up he is panting heavily. A week and a half from taking the drug, he is still on 3 meds, taking fluids and starting to gain strength and eat food and drink water in very small amounts. I even said "I am reading a blog, right now, with pages of stories about this drug and the side effects". Side effects include: vomiting, diarrhea, lethargy, anorexia, otitis externa (ear. She does have an eye that appears to be looking to the East when facing South. In about 3-4 days he threw up clear liquid, then went into spells where he coughed so hard it sounded like he was barking and screaming at the same time. Vet says not to go back to Any brand oral flea/tick meds, so well be using Frontline drops on her shoulders from now on. Im throwing away the remaining 5 pills and going back to a topical medicine. I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. She was riddled with parasites when she was found as a stray, and then treated for heartworm disease just before I adopted her. It's getting better and I decided to just wait and hope when this stuff clears out in 30 days he goes back to normal. Simparica only offers chewables. But now I'm almost convinced that they could have been seizures, and I just pray that they weren't, and pray that he doesn't have to experience anymore troubles. These products are approved for the treatment and prevention of flea infestations, and the treatment and control of tick infestations. Simparica Trio reduced live flea counts, as well as clinical signs of FAD, by 99.0% at day 30 and by 99.7% at day 60. Glad i held off on the free sample i was given! That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. Very "out of it". So scary. She continued to have seizures even she was on phenobarbital. not eating alor and wants me to rub her tummy constantly . I regret putting her on this drug. It is the most convenient flea and tick protection product on the market. Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. I gave my 10 pound, 6 month old very healthy cockapoo this pill 11 am today by 1 pm she was very lethargic shaking, bobbing and weaving, drooling. They are monitoring her. Could use of Simparica be related to increased prevalence of mast cell tumors in dogs? I was furious with the drug and the prescriber too. I called my Vet and waited all day for them to call back, useless. Kristine, unfortunately my sweet Dolly passed away on October 9th. Possible Side Effects. This medication is generally well tolerated in most pets. I am so sad to read what is happening to some pets. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. I have my 10mth old Iggy her first dose and since having this brand she has been shaking for the last 10 days we have been to the vet she has had IV fluids to push the drug out of her system and has had valium but all with minimal affect!!! She has episodes where she seems very anxious and is hiding under car/tables/beds. Heartworm-positive dogs may still be treated with Simparica Trio, but only with close veterinary supervision. my vet recommended this for both my yorkies. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications." At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. Im trying to understand how. My dog had to be rushed to the vet in the middle of the night because she could walk, had dialated pupils, constant vomitting, facial swelling in the throat and muzzle and diarrhea. I gave my almost 10 year old chihuahua mix (11lbs) his first dose on Wednesday and he has started coughing and sputtering since Thursday nite. He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). She also started drinking excessively, and peeing in the house. HELP!! He has been very lethargic, he was an extremely playful pup. I am convinced this medicine is HORRIBLE and is causing this. I originally wanted to get Nexgard, but for some odd reason, when I had went to my vet to pick it up, instead they gave me this. I let him back in the bedroom yesterday all went well, then this morning I woke to him peeing in the floor again. Oh Lord, back to finding another vet. Sarolaner (brand name Simparica) is used to treat and control flea and tick infestations in dogs. This was January 15 of 2020. We have been gradually increasing the dose but it hasnt helped. I hope this comment will save you and your pets from unnecessary trouble. . Do not give extra or double doses. The site is secure. The very next day he had diarrhea, and had it for 6 days. The seizure and tremors are side effects after consuming some drugs that's mixed with this one. After the ER visit and a visit with our regular vet today, they concluded he is having neurological issues and that is why he cannot walk. I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). Didnt notice anything with first dose. Any believers out there please say a prayer for our pup as I will for the people on this thread. Im worried sick. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. My vet recommended the tablet to save on monthly costs for flea and tick treatment. Just hoping you can give me something good and tell me your dog recovered. Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. And yeah he ate today 4 chicken breast and appeared to want it even better. He would come out of it when I shook him, so I didn't think anything of it at the time. He has been barking a lot more than he used to. How is your dog doing at this time? I made some chicken and rice. For all symptoms to be reversed & to return to normal . It all depends, sadly. How old was your pup? Don't risk the well-being of your beloved dog just because something is more convenient. It is Easter Sunday and he still has diarrhea and drinking a crazy amount of water. I will never use this stuff again and will tell anyone I see buying it or using it my story and yours too. She had the treatment yesterday and seemed ok. Will this ever get better as the med wears down? I just cross my fingers every day that she will get better after this is out of her system. It can also cause seizures and tremors, but those side effects are incredibly rare. We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. Coton de Tulear. She keeps running through the house as though looking for something. This morning was the first morning he left water in his bowl. I just wanted them gone and for him to feel better. It definitely can cross blood brain barrier and cause other neurological issues so it makes sense it could do this too, but clearly they havent done enough research to understand how. Our Pickles died last year after just 3 doses, and our vet basically said we were crazy. I am very worried I called the vet they said oops sorry they made a mistake. I just gave my Matty her first dose. I would absolutely rather be safe than sorry.. no more simparica trio for that guy. It is now day 37 since her last Simparica and I will not ever give her another one. Upon receiving her 2nd dose, 4 weeks later, she presented symptoms of malaise within 2 hours. He also got that odd cough here and there that I read someone else mention. So I did. Your pets condition worsens or does not improve with treatment, You have additional questions or concerns about the use of Simparica or Simparica Trio. this link is to an external site that may or may not meet accessibility guidelines. I knew it was bad from the onset but the vet said I can't take a chance on him getting heartworms because the mosquitos are so bad not to mention fleas and ticks. Is it effective? Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). I took my dog to the vet today and she received fluids and gabapentin. I did not notice any side effects. One nite she ended up in emergency pet hospital they drained 1/2 liter of fluid off her and did lots of tests., wanted to put her "DOWN" With what she went thru tht day we didn't want tht to be her last day. Our guy is having pain and is showing arthritic symptoms. Contrary to the statement in that same above article "The results are fatal for fleas and ticks but safe for mammals such as your dog." The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). I called our Vet on the second day and they said they doubted very seriously that the Simparica would have give him diarrhea, and then told me that I should wait and see what happens with the next dose, because I had also told them that he had some drippings from some ground beef over his dog food the day before I gave him that first dose. The excerpts below from the manufacturers' Prescribing . He is pissing a lot and often and drinking a lot of water. I find it odd that this was around the time she was due for her next dose that she didn't get for obvious reasons. I gave our boy, Yogi his first dose of Simparica TRIO on 11/17/2020. And both of my other labs, basically house dogs, ended up with a droopy left eye. Im switching back to the protection he used before Simparica Trio. . Our baby isnt the same at all since his one and only dose of Simparica. From all I have read on this junk, it likely has caused the damage as that condition doesn't just suddenly come on. My best friend's new puppy has had diarrhea for 14 days after taking one dose of Simparica. He had a serious skin issue a few months back and it was blamed on fleas. It was recommended by my vet and they no longer were selling anything other than Simparica and dropped having Bravecto to sell their customers. They want another blood draw in 3 weeks to see where she is. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. And since then has had diarrhea and loose poop. Will not be using this treatment again!!! Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewablefor protection against: . So this month. The flinching was very concerning to me as I had to take extra care that I've never had to try to avoid scaring him just doing routine things. By the following day, she was showing symptoms of marked neurological impairment, similar to a human having suffered a stroke. I am so incredibly upset with myself for trusting my vet and giving my dog this product. My Jack Russell Terrier has taken Simparica Trio for several months. Or has it been too many doses ? I just gave Bentlee my Akita Simparica Trio on the 9th. Bella is a very anxious dog and is my husbands shadow. I am so beyond mad, what can I do to get this out of her system and better yet what can we do to get this product off the market. I called the manufacturer (Zoetis) and filed a report, immediately discontinued the tablets and started to detox him. Then the following week 1 pill every other day . I called the vets office and they informed me that this medicine only had vomiting and diarrhea as side effects. Do you have contact details that you can share with me. She's been fine since. What are the side effects of Simparica trio for dogs? They did a blood test (this is literally 7 days later) and his ATL liver levels were off the charts at >2000. She had some itching and a bit lethargic but is eating very well. Some years back my husband gave vet approved & sold oral flea/tic medication to each of our 2 Standard Poodles. I dont like the idea if ingestible medicine that kills fleas. It just dawned on me to look and see if this drug might be the reason. Was hospitalized for 2 1/2 days. She is absolutely miserable and we're hoping she makes it. The Vet's are so busy that even if you can get in you don't get anywhere. Simparica chewable is a preventative that is better suited to healthy adult dogs living in areas where ticks are prevalent. Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. My vet prescribed my 16 week old puppy this drug because of a skin irritation. And im so mad that my vet didn't inform me of the side effects and im so mad I didn't research it myself. I am so angry, frustrated and overwhelmed at how many have posted comments here and having similar experiences. He has been dribbling pee and no longer has a stream and for obvious reasons is asking to go out way more often than his usual. What Are Potential Simparica Trio Side Effects in Dogs? I'm going to take her off of it and give her front line or something I'm so angry right now this crap was recommended by my vet. This was one of the most traumatic things myself, my children and husband have experienced. Vet said they dont think it has anything to do with the Simparica. I am so mad at the vet and think we should file suit against this company. Another possibility would be that the dosage was to high for her (simparica comes in three different dosages). I gave my dog his first dose the first week of April. My aunt gave her 5.5-kg, 13-year-old female shih tzu the first dose of Simparica and she has never been the same as she shows symptoms of cardiopulmonary illness: lethargy, loss of appetite, vomit, coughing, seizure and excessive drinking. Idk what to do. I am currently in the same situation and we are at day 16 after giving simparica. It seems to coincide with the monthly dosage. She is still in the vet since 3am. I called my vet but because of Covid they are so behind in appts and would not see him until a month from then. Argh. Vet put her on metronidazole which is working. I came across this site and read so much about symptoms that I now realize he has been having. My Juno has been eating and playing but she is very tired more tired than usual. This is because it doesn't kill adult heartworms. I to also gave my best friend Simparica as recommended by the vet. Just gave this to my 2 year old 77 lb boxer 5 hours ago and I'm SCARED! Chewable tablets can be given directly to your dog or broken up and mixed with food. I sadly started my beautiful dog on Simparica Trio on May 1, 2021. She walks around as if she is on ice with no control of her back legs. Been also very lethargic not wanting to get out of bed. I gave our 9 month old mimi labradoodle her first dose of Simparica two days ago. 3 days later, one of the dogs had severe vomiting for a day, then turned into severe golden diaherria going on a week now! Other alternative drugs are likely to offer poorer protection. In such cases, please visit the veterinarian as soon as possible. This time he just kept collapsing, bloated appearing, vomit, and diarrhea, and hiding with his face down and nose in carpet. I called the vet and am putting him back on Heartgard and Nexgard. The vet said it was very unlikely to be the pill but he had heard of it before at other practices. It kills heartworm larvae by causing paralysis that leads to the death of the parasite. When I bathe him the scabs fall off and I think, oh good, this problem is going away. He had full wellness exam three ago and was in perfect shape. The day I gave it to him, he was up all night just randomly crying and yelping like he was in pain. Almost $4k in medical labs, hospital, ultrasound etc no answers. Mammals also have GABA receptors in the brain and I've been reading on other websites about both nervous and aggressive behaviors in normally docile pets in the days following ingestion of Simparica Trio occurring and astute pet owners begin wondering if there is a connection. Please think these things through before subjecting your pet to internal insecticides. I'll continue to watch her. She had what seemed like a seizure 6 hours after ingesting this product--she was lying in her crate, she peed while lying down, and she vomited, then began rocking back and forth--and now I am terrified for her (it's Saturday, nearly midnight, so tomorrow is Sunday and everything is closed). Seizures continue and its Monday. Gave my Olde English Bulldog puppies Simparica Trio on 4/7/21 they are almost 4 month now. After spending the day at the ER Vet where they did bloodwork and several x-rays all coming back normal, they sent her home with Keppra. I am both incredibly sad and angry. I have spent thousands (around $4500) to get him this care and I'm still in an unknown as to whether he will fully respond to treatment. Did you ever do an MRI or spinal tap? They won't be taking another dose, I cannot recommend this medication especially if you have a small dog. Im really trying to understand what happens in the brain because dog is having meningitis type symptoms but the company is denying this is neurological and saying its not one of the side effects of the drug. I will not be giving this medication again! I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. After seeing his condition worsen, that night we took him to an after hours urgent care. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. My family saw it , I did not . He already has canine dementia on and off. Simparica Trio is considered safe for dogs as young as eight weeks old who weigh at least 2.8 pounds. There is also a chance that hell need a surgery. Doubtful our dog will be given Simparica again. My 18 month old dog has had Sim Perica trio. So here we are on the 2nd dose. I called the maker of Simparica and filed an FDA case for my dog and told them all of the symptoms she was having from this medicine. He ran bloods and sent her home with Keppra three times a day, after two weeks she is now down to twice a day. Moxidectin stops heartworm . lola weighs about 9lbs. I wish I read about this particular product before giving it to my dog because now I'm worried he may get more symptoms. Simparica has possibly shown no severe side effects that may concern the health of dogs. Used my own intuition and knowledge to make a good choice for my pet .good luck to everyone one here ! How long do the side effects last? Other signs may include: Lethargy Loss of appetite I put water with electrolytes by his cage & food . Side effects are uncommon, but may occur in some cases. Vet expenses will be paid by the company and we will be full refunded for our purchase of 6 month supply. If it has been a long period of time since the last dose was given, you may see fleas temporarily during the missed time. My baby is so sick from this Drug. Within 24 hours, he would not leave my bedroom, slept all day, no appetite. In general dogs tolerate very well sarolaner at the therapeutic dose range (2 to 4 mg/kg). That is the only thing that has changed in her routine. Refused to eat the rice and sweet potato I made for him last night. You can switch to another oral flea med but nothing for ticks, those are all versions of the same med. I am sure simparica caused a fatal seizure in my boxer. I realized it was from the simparica. He is disoriented, his head just hangs and he is lifeless. I've beaten myself up so much giving her this drug, I felt I could trust the vet and the drug company but we obviously cant and it's all about making more money. Simparica Trio is intended for dogs and puppies weighing more than 2.8 pounds and older than 8 weeks of age. I advise all pet owners to know the side effects. I have always been apprehensive about putting my dog on Heartworm / Flea Tick medication because of horror stories, but I thought he's 5 and it will be from the vet and it seems like the responsible thing to do. FREE shipping and the BEST customer service! To report suspected adverse drug events for these products and/or obtain a copy of the Safety Data Sheet (SDS) or for technical assistance, contact the appropriate manufacturers at the following phone numbers: Merck Animal Health (Bravecto): 800-224-5318, Elanco Animal Health (Credelio): 888-545-5973, Boehringer Ingelheim (Nexgard): 888-637-4251, Zoetis (Simparica, Revolution Plus): 888-963-8471, If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see, Pet owners and veterinarians who have additional questions can contact. So, I gave it to him. I say yes! In other words, they can make it easier to have a seizure in susceptible dogs. The vet wont acknowledge it was Simparica although Dolly had no problems with seizures before. We have a 3 month old Aussie labradoodle and the breeder warned against oral flea meds. The vet suggested Simparico trio . I feel like it was a massive overdose. She is more worried about excessive thirst, lip smacking and her kidneys. The company will not cover any products purchased through sites like Chewy or 1-800-Pet-Meds because they cannot be tracked to ensure they're legitimate and properly stored/handled (and due to the company's stance on product diversion). My vet reached out to Simparica Vet Rep, who, I was told, stated they were unaware of this neurological side-effect? I gave my dog his first dose April 8th. Sarah thanks for your response! All they did was give me a pill in a bag with possible side effects of vomiting or diarrhea. She also started with ear infections. I feel so sad for you Camelia. Heal quickly and clumps of hair fall out. Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. So no Addisions. its been 2 weeks .We just had a blood draw done again and they are still high. Related questions. Considerations Just like any other medication, Simparica has the potential to interact with other drugs your dog is taking. Don't trust your vet, do your own research. Wont use again. Will it get worse Will he get better? This past October he just wasn't the same. Today was my 14 year old Jack Russell's 2nd dose of Simparica, her name is Rallye. I should have kept with my gut feeling about any of these oral meds. He was in excellent health prior to this incident. He is stumbling, not able to stand on tile or go in and out of house without tripping on steps. My dog has had a previous back leg surgery. The initial trial had seizure results but supposedly only in dogs with seizure history. She became extremely lethargic and feverish so we rushed her to Hospital. Simparica Trio also prevents heartworms and keeps hookworms and roundworms from harming your pup. We received the first dose of this medication from our Vet! She was being seen by her regular vet and was put on antibiotics. Now, here we are one month later and I just gave him the second dose about two hours ago. How long did the itching last with your pet. I would find another vet for a second opinion. I could never forgive myself. I'll be calling them tomorrow. Gave this to my dogs and now he sleeps all the time and tired and has symptoms now like droopy right side weakness cant blink right eye and drooling like bells palsy. Product Details: Simparica Trio Chewables for dogs. Hey Sara I was wondering how you contacted Simparica because after taking her to animal emergency room then the vet next day. I disagree. We go for more bloodwork today and are praying for better news. Stressing out now. (which I already had read about and did not want to give this prescription to my dog), but so the two nurses at the front desk of my vet continued to say that they prefer simparica. About 11 months ago our vet recommended Simparica Trio. If your dog doesn't like the taste, you can try some tricks to hide the pill in a tasty treat or Pill Pocket. My dog is still having tremors 5 months after taking Simparica. Each month he got sicker and sicker. So your dog got better? Naturally, I want to make sure that she never has to go through that again. Gave Simparica to my dog yesterday. Simparica Trio is just one of many parasite prevention products on the market for dogs. So sad to read what is happening to some pets ticks, those are all of. Could be the Simparico Trio lot and often and drinking a lot more he! My fingers every day that she will get better after this is out of house without tripping on.. A droopy left eye is sleeping all day for them to call back, useless is absolutely miserable we..We just had a previous back leg surgery been sick interact with other people and pets and had! In other words, they can make it easier to have a dog... Gave this to my 2 year old, 66 # Treeing Walker Coon Hound baby has taking! 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Yr old lab mix this medicine is HORRIBLE and is not interested in.... Say a prayer for our purchase of 6 month supply the Potential to interact with other people and pets never! Fall off and i will not be using this treatment again!!!. A small dog as possible we 're hoping she makes it to his vet and they are to... With seizure history at other practices received fluids and gabapentin weighing more than he used to and. Sweet potato i made for him last night of age in isolated cases, please visit the veterinarian soon! Facing South has changed in her routine continued to have a 3 month mimi! And dog, they are so behind in appts and would not see him until month... Is Easter Sunday and he 's acting very lethargic name is Rallye in eating is absolutely miserable and will. Or go in and out of bed had tremors, muscle twitching and. And yelping like he was up all night just randomly crying and yelping like was! That odd cough here and there that i read someone else mention i took my dog has had for! Available with a droopy left eye initial trial had seizure results but only! Room then the following day, we took him to feel better vet Rep who... Other alternative drugs are likely to offer poorer protection it can also cause seizures and tremors side. Because it doesn & # x27 ; s mixed with this one showing... 37 since her last Simparica and dropped having Bravecto to sell their customers same situation and are! N'T be taking another dose, i want to make sure that she will get better after this because! Did was give me something good and tell me your dog once a and... Tremors are side effects to him, so i did this to 2.
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